Effect of FR145237, a novel ACAT inhibitor, on atherogenesis in cholesterol-fed and WHHL rabbits. Evidence for a direct effect on the arterial wall
M Matsuo, F Ito, A Konto, M Aketa, M Tomoi… - … et Biophysica Acta (BBA …, 1995 - Elsevier
The hypocholesterolemic and antiatherosclerotic activities of FR145237, a novel acyl-CoA:
cholesterol acyltransferase (ACAT) inhibitor, were evaluated in cholesterol-fed and
Watanabe heritable hyperlipidemic (WHHL) rabbits. In the first experiment, rabbits were fed
a high cholesterol (1% cholesterol) diet for 2 weeks and further fed a high cholesterol diet
containing FR145237 for 8 weeks. FR145237 (0.1, 0.32 and 1.0 mg/kg) dose-dependently
lowered the plasma total cholesterol levels by 80%, 96% and 97%, respectively, and …
cholesterol acyltransferase (ACAT) inhibitor, were evaluated in cholesterol-fed and
Watanabe heritable hyperlipidemic (WHHL) rabbits. In the first experiment, rabbits were fed
a high cholesterol (1% cholesterol) diet for 2 weeks and further fed a high cholesterol diet
containing FR145237 for 8 weeks. FR145237 (0.1, 0.32 and 1.0 mg/kg) dose-dependently
lowered the plasma total cholesterol levels by 80%, 96% and 97%, respectively, and …