[HTML][HTML] The human copper-zinc superoxide dismutase gene (SOD1) proximal promoter is regulated by Sp1, Egr-1, and WT1 via non-canonical binding sites
E Minc, P De Coppet, P Masson, L Thiery… - Journal of Biological …, 1999 - ASBMB
Human copper-zinc superoxide dismutase (Cu, Zn-SOD) participates in the control of
reactive oxygen intermediate intracellular concentration. In this study, we show that phorbol
12-myristate 13-acetate (PMA) increases Cu, Zn-SOD mRNA expression within 30 min. The
sequence between nucleotides− 71 and− 29 is essential for both basal and PMA-induced
gene expression. This region includes an Sp1-binding site that is also recognized by a
possible Sp1-like protein and by Egr-1 in a PMA-inducible manner. Egr-1 and two splicing …
reactive oxygen intermediate intracellular concentration. In this study, we show that phorbol
12-myristate 13-acetate (PMA) increases Cu, Zn-SOD mRNA expression within 30 min. The
sequence between nucleotides− 71 and− 29 is essential for both basal and PMA-induced
gene expression. This region includes an Sp1-binding site that is also recognized by a
possible Sp1-like protein and by Egr-1 in a PMA-inducible manner. Egr-1 and two splicing …