[HTML][HTML] Early growth response-1-dependent apoptosis is mediated by p53
P Nair, S Muthukkumar, SF Sells, SS Han… - Journal of biological …, 1997 - ASBMB
The early growth response-1 (EGR-1) protein is an anti-proliferative signal for certain tumor
cells and is required for apoptosis induced by stimuli that elevate intracellular Ca 2+. We
present evidence that EGR-1 transactivates the promoter of the p53 gene and up-regulates
p53 RNA and protein levels. Inhibition of p53 function with dominant-negative p53 mutants
abrogates EGR-1-dependent apoptosis. These findings establish a direct functional link
between EGR-1 and the p53-mediated cell death pathway and suggest that mutant forms of …
cells and is required for apoptosis induced by stimuli that elevate intracellular Ca 2+. We
present evidence that EGR-1 transactivates the promoter of the p53 gene and up-regulates
p53 RNA and protein levels. Inhibition of p53 function with dominant-negative p53 mutants
abrogates EGR-1-dependent apoptosis. These findings establish a direct functional link
between EGR-1 and the p53-mediated cell death pathway and suggest that mutant forms of …