Control of adrenal androgen secretion

LN Parker, WD Odell - Endocrine reviews, 1980 - academic.oup.com
LN Parker, WD Odell
Endocrine reviews, 1980academic.oup.com
The human adrenal cortex secretes a variety of androgens, as shown in Fig. 1, in addition to
cortisol and aldosterone. Some of these steroids function as androgens, or serve as
precursors for androgen or estrogen formation in peripheral tissues. The control of
glucocorticoid and mineralocorticoid secretion is largely under the influence of ACTH and
the renin-angiotensin system, respectively. However, the mechanism of control of adrenal
androgen (AA) secretion is less well defined, and is the main subject of this review.
The human adrenal cortex secretes a variety of androgens, as shown in Fig. 1, in addition to cortisol and aldosterone. Some of these steroids function as androgens, or serve as precursors for androgen or estrogen formation in peripheral tissues. The control of glucocorticoid and mineralocorticoid secretion is largely under the influence of ACTH and the renin-angiotensin system, respectively. However, the mechanism of control of adrenal androgen (AA) secretion is less well defined, and is the main subject of this review.
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