[HTML][HTML] The sins of the fathers and mothers: genomic imprinting in mammalian development
SM Tilghman - Cell, 1999 - cell.com
SM Tilghman
Cell, 1999•cell.com), came as quite a surprise and forced classical Mendelian genetics to undergo a number of
revisions. The discovery of imprinting also presents us with a genetic paradox: by silencing
one allele of an autosomal gene, mammals discard the advantage of diploidy. What are
parents trying to achieve with this heavy-handed way of influencing gene expression in their
offspring? This article will focus on that issue, as well as outstanding issues regarding the
mechanism of imprinting.
revisions. The discovery of imprinting also presents us with a genetic paradox: by silencing
one allele of an autosomal gene, mammals discard the advantage of diploidy. What are
parents trying to achieve with this heavy-handed way of influencing gene expression in their
offspring? This article will focus on that issue, as well as outstanding issues regarding the
mechanism of imprinting.
), came as quite a surprise and forced classical Mendelian genetics to undergo a number of revisions. The discovery of imprinting also presents us with a genetic paradox: by silencing one allele of an autosomal gene, mammals discard the advantage of diploidy. What are parents trying to achieve with this heavy-handed way of influencing gene expression in their offspring? This article will focus on that issue, as well as outstanding issues regarding the mechanism of imprinting.
cell.com