T Cell Telomere Length in HIV-1 Infection: No Evidence for Increased CD4+ T Cell Turnover
KC Wolthers, G Bea, A Wisman, SA Otto… - Science, 1996 - science.org
KC Wolthers, G Bea, A Wisman, SA Otto, AM de Roda Husman, N Schaft, F de Wolf…
Science, 1996•science.orgProgression to acquired immunodeficiency syndrome (AIDS) has been related to exhaustion
of the regenerative capacity of the immune system resulting from high T cell turnover.
Analysis of telomeric terminal restriction fragment (TRF) length, a marker for cellular
replicative history, showed that CD8+ T cell TRF length decreased but CD4+ T cell TRF
length was stable during the course of human immunodeficiency virus type-1 (HIV-1)
infection, which was not explained by differential telomerase activity. This observation …
of the regenerative capacity of the immune system resulting from high T cell turnover.
Analysis of telomeric terminal restriction fragment (TRF) length, a marker for cellular
replicative history, showed that CD8+ T cell TRF length decreased but CD4+ T cell TRF
length was stable during the course of human immunodeficiency virus type-1 (HIV-1)
infection, which was not explained by differential telomerase activity. This observation …
Progression to acquired immunodeficiency syndrome (AIDS) has been related to exhaustion of the regenerative capacity of the immune system resulting from high T cell turnover. Analysis of telomeric terminal restriction fragment (TRF) length, a marker for cellular replicative history, showed that CD8+ T cell TRF length decreased but CD4+ T cell TRF length was stable during the course of human immunodeficiency virus type-1 (HIV-1) infection, which was not explained by differential telomerase activity. This observation provides evidence that turnover in the course of HIV-1 infection can be increased considerably in CD8+ T cells, but not in CD4+ T cells. These results are compatible with CD4+ T cell decline in HIV-1 infection caused by interference with cell renewal.
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