Early growth response protein 1 (Egr-1): prototype of a zinc-finger family of transcription factors
A Gashler, VP Sukhatme - Progress in nucleic acid research and molecular …, 1995 - Elsevier
Publisher Summary This chapter discusses the early growth response protein (Egr) gene
family and its most extensively characterized member, Egr-1, first identified as an immediate-
early gene responsive to growth factors and various differentiation cues, later confirmed to
be a transcriptional regulatory protein. During development, a single Egr-1 transcript is
predominantly expressed in cortex, midbrain, and cerebellum; in bone, cartilage, and
muscle; and at several sites of epithelial-mesenchymal interactions. In addition, Egr-1 is …
family and its most extensively characterized member, Egr-1, first identified as an immediate-
early gene responsive to growth factors and various differentiation cues, later confirmed to
be a transcriptional regulatory protein. During development, a single Egr-1 transcript is
predominantly expressed in cortex, midbrain, and cerebellum; in bone, cartilage, and
muscle; and at several sites of epithelial-mesenchymal interactions. In addition, Egr-1 is …