[HTML][HTML] The NH2-terminal region of apolipoprotein B is sufficient for lipoprotein association with glycosaminoglycans
IJ Goldberg, WD Wagner, L Pang, L Paka… - Journal of Biological …, 1998 - ASBMB
An initial event in atherosclerosis is the retention of lipoproteins within the intima of the
vessel wall. The co-localization of apolipoprotein (apo) B and proteoglycans within lesions
has suggested that retention is due to lipoprotein interaction with these highly
electronegative glycoconjugates. Both apoB100-and apoB48-containing lipoproteins, ie low
density lipoproteins (LDLs) and chylomicron remnants, are atherogenic. This suggests that
retention is due to determinants in the initial 48% of apoB. To test this, the interaction of an …
vessel wall. The co-localization of apolipoprotein (apo) B and proteoglycans within lesions
has suggested that retention is due to lipoprotein interaction with these highly
electronegative glycoconjugates. Both apoB100-and apoB48-containing lipoproteins, ie low
density lipoproteins (LDLs) and chylomicron remnants, are atherogenic. This suggests that
retention is due to determinants in the initial 48% of apoB. To test this, the interaction of an …