[HTML][HTML] Hepatic overexpression of microsomal triglyceride transfer protein (MTP) results in increased in vivo secretion of VLDL triglycerides and apolipoprotein B

UJF Tietge, A Bakillah, C Maugeais, K Tsukamoto… - Journal of lipid …, 1999 - ASBMB
The microsomal triglyceride transfer protein (MTP) is essential for the hepatic secretion of
apolipoprotein (apo) B-containing lipoproteins. Previous studies have indicated that
inhibition of MTP results in decreased apoB plasma levels and decreased hepatic
triglyceride secretion. However, the metabolic effects of overexpression of MTP have not
been investigated. We constructed a recombinant adenovirus expressing MTP (AdhMTP)
and used it to assess the effects of hepatic overexpression of MTP in mice. Injection of …