Decreased autoantibody levels and enhanced survival of (NZB× NZW) F1 mice treated with C-reactive protein
TW Du Clos, LT Zlock, PS Hicks, C Mold - Clinical immunology and …, 1994 - Elsevier
C-Reactive protein (CRP) is the prototypic acute-phase serum protein in man. On the basis
of its binding specificities and activities, it has been proposed that CRP facilitates the
removal of nuclear material released from damaged cells. To determine whether such a
process could alter the development of autoimmunity to nuclear antigens, the effect of CRP
on autoimmune disease in the (NZB× NZW) F1 mouse model of systemic lupus
erythematosus was tested. Mice were injected with chromatin bound to latex beads in the …
of its binding specificities and activities, it has been proposed that CRP facilitates the
removal of nuclear material released from damaged cells. To determine whether such a
process could alter the development of autoimmunity to nuclear antigens, the effect of CRP
on autoimmune disease in the (NZB× NZW) F1 mouse model of systemic lupus
erythematosus was tested. Mice were injected with chromatin bound to latex beads in the …