Ligand-independent repression by the thyroid hormone receptor mediated by a nuclear receptor co-repressor
Nature, 1995•nature.com
Thyroid-hormone and retinoic-acid receptors exert their regulatory functions by acting as
both activators and repressers of gene expression. A nuclear receptor co-repressor (N-CoR)
of relative molecular mass 270K has been identified which mediates ligand-independent
inhibition of gene transcription by these receptors, suggesting that the molecular
mechanisms of repression by thyroid-hormone and retinoic-acid receptors are analogous to
the co-repressor-dependent transcriptional inhibitory mechanisms of yeast and Drosophila.
both activators and repressers of gene expression. A nuclear receptor co-repressor (N-CoR)
of relative molecular mass 270K has been identified which mediates ligand-independent
inhibition of gene transcription by these receptors, suggesting that the molecular
mechanisms of repression by thyroid-hormone and retinoic-acid receptors are analogous to
the co-repressor-dependent transcriptional inhibitory mechanisms of yeast and Drosophila.
Abstract
Thyroid-hormone and retinoic-acid receptors exert their regulatory functions by acting as both activators and repressers of gene expression. A nuclear receptor co-repressor (N-CoR) of relative molecular mass 270K has been identified which mediates ligand-independent inhibition of gene transcription by these receptors, suggesting that the molecular mechanisms of repression by thyroid-hormone and retinoic-acid receptors are analogous to the co-repressor-dependent transcriptional inhibitory mechanisms of yeast and Drosophila.
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