ATP-dependent transport of glutathione S-conjugates by the multidrug resistance protein MRP1 and its apical isoform MRP2
The membrane proteins mediating the ATP-dependent transport of glutathione S-conjugates
and related amphiphilic anions have been identified as the multidrug resistance proteins
MRP1 and MRP2. These 190-kDa membrane glycoproteins were cloned in recent years and
shown to be unidirectional, ATP-driven, export pumps with an amino acid identity of 49% in
humans. MRP1 is detected in the plasma membrane of many cell types, including
erythrocytes; whereas MRP2, also termed canalicular MRP (cMRP) or canalicular …
and related amphiphilic anions have been identified as the multidrug resistance proteins
MRP1 and MRP2. These 190-kDa membrane glycoproteins were cloned in recent years and
shown to be unidirectional, ATP-driven, export pumps with an amino acid identity of 49% in
humans. MRP1 is detected in the plasma membrane of many cell types, including
erythrocytes; whereas MRP2, also termed canalicular MRP (cMRP) or canalicular …