Competitive PCR quantification of pro-and anti-inflammatory cytokine mRNA in the central nervous system during autoimmune encephalomyelitis
N Tanuma, T Kojima, T Shin, Y Aikawa, T Kohji… - Journal of …, 1997 - Elsevier
Experimental autoimmune encephalomyelitis (EAE) is an inflammatory disease of the
central nervous system that can be induced by immunization with myelin basic protein
(MBP)/complete Freund's adjuvant and serves as a model for multiple sclerosis. Recent
studies have suggested that cytokines play a crucial role in the clinical course of EAE. To
clarify the roles of cytokines in EAE, we examined levels of interferon-γ (IFN-γ), tumor
necrosis factor-α (TNF-α), transforming growth factor-β1 (TGF-β1) and interleukin-10 (IL-10) …
central nervous system that can be induced by immunization with myelin basic protein
(MBP)/complete Freund's adjuvant and serves as a model for multiple sclerosis. Recent
studies have suggested that cytokines play a crucial role in the clinical course of EAE. To
clarify the roles of cytokines in EAE, we examined levels of interferon-γ (IFN-γ), tumor
necrosis factor-α (TNF-α), transforming growth factor-β1 (TGF-β1) and interleukin-10 (IL-10) …