We have recently developed approaches for the generation of encephalitogenic T cell
clones from mouse strains considered resistant to experimental allergic encephalomyelitis
(EAE). By allowing for the direct use of knockout and mutant strains of mice, such clones
allow for the efficient characterization of the relevance of specific gene products in the
effector phase of EAE. Recent studies have suggested that Fas/FasL-mediated cell death
may play a role in the pathogenesis of MS. To assess the role of Fas/FasL in EAE, we have …