Mechanisms of recovery from experimental autoimmune encephalomyelitis: T cell deletion and immune deviation in myelin basic protein T cell receptor transgenic …
Y Chen, WW Hancock, R Marks, P Gonnella… - Journal of …, 1998 - Elsevier
Experimental autoimmune encephalomyelitis (EAE) is a Th1-type cell-mediated
autoimmune disease directed against central nervous system (CNS) myelin antigens such
as myelin basic protein (MBP). EAE is usually characterized by spontaneous remission of
clinical disease and immune pathology despite the persistence of self myelin antigens in the
central nervous system. Following induction of an acute episode of EAE, spontaneous
remission also occurs in MBP T cell receptor (TCR) transgenic mice even though most T …
autoimmune disease directed against central nervous system (CNS) myelin antigens such
as myelin basic protein (MBP). EAE is usually characterized by spontaneous remission of
clinical disease and immune pathology despite the persistence of self myelin antigens in the
central nervous system. Following induction of an acute episode of EAE, spontaneous
remission also occurs in MBP T cell receptor (TCR) transgenic mice even though most T …