[HTML][HTML] Defective secretion of saliva in transgenic mice lacking aquaporin-5 water channels
T Ma, Y Song, A Gillespie, EJ Carlson… - Journal of Biological …, 1999 - ASBMB
Aquaporin-5 (AQP5) is a water-selective transporting protein expressed in epithelial cells of
serous acini in salivary gland. We generated AQP5 null mice by targeted gene disruption.
The genotype distribution from intercross of founder AQP5 heterozygous mice was 70: 69:
29 wild-type: heterozygote: knockout, indicating impaired prenatal survival of the null mice.
The knockout mice had grossly normal appearance, but grew∼ 20% slower than litter-
matched wild-type mice when placed on solid food after weaning. Pilocarpine-stimulated …
serous acini in salivary gland. We generated AQP5 null mice by targeted gene disruption.
The genotype distribution from intercross of founder AQP5 heterozygous mice was 70: 69:
29 wild-type: heterozygote: knockout, indicating impaired prenatal survival of the null mice.
The knockout mice had grossly normal appearance, but grew∼ 20% slower than litter-
matched wild-type mice when placed on solid food after weaning. Pilocarpine-stimulated …