Brain contains HNK-1 immunoreactive O-glycans of the sulfoglucuronyl lactosamine series that terminate in 2-linked or 2, 6-linked hexose (mannose)
CT Yuen, W Chai, RW Loveless, AM Lawson… - Journal of Biological …, 1997 - ASBMB
The monoclonal antibody HNK-1 originally raised to an antigenic marker of natural killer
cells also binds to selected regions in nervous tissue. The antigen is a carbohydrate that has
attracted much interest as its expression is developmentally regulated in nervous tissue, and
it is found, and proposed to be a ligand, on several of the adhesive glycoproteins of the
nervous system. It is also expressed on glycolipids and proteoglycans, and is the target of
monoclonal auto-antibodies that give rise to a demyelinating disease. The epitope, as …
cells also binds to selected regions in nervous tissue. The antigen is a carbohydrate that has
attracted much interest as its expression is developmentally regulated in nervous tissue, and
it is found, and proposed to be a ligand, on several of the adhesive glycoproteins of the
nervous system. It is also expressed on glycolipids and proteoglycans, and is the target of
monoclonal auto-antibodies that give rise to a demyelinating disease. The epitope, as …
