[HTML][HTML] ApoA-II maintains HDL levels in part by inhibition of hepatic lipase: studies in apoA-II and hepatic lipase double knockout mice
W Weng, NA Brandenburg, S Zhong, J Halkias… - Journal of lipid …, 1999 - ASBMB
High density lipoprotein (HDL) cholesterol levels are inversely related to the risk of
developing coronary heart disease. Apolipoprotein (apo) A-II is the second most abundant
HDL apolipoprotein and apoA-II knockout mice show a 70% reduction in HDL cholesterol
levels. There is also evidence, using human apoA-II transgenic mice, that apoA-II can
prevent hepatic lipase-mediated HDL triglyceride hydrolysis and reduction in HDL size.
These observations suggest the hypothesis that apoA-II maintains HDL levels, at least in …
developing coronary heart disease. Apolipoprotein (apo) A-II is the second most abundant
HDL apolipoprotein and apoA-II knockout mice show a 70% reduction in HDL cholesterol
levels. There is also evidence, using human apoA-II transgenic mice, that apoA-II can
prevent hepatic lipase-mediated HDL triglyceride hydrolysis and reduction in HDL size.
These observations suggest the hypothesis that apoA-II maintains HDL levels, at least in …
