Analogs of staurosporine: potential anticancer drugs?
A Gescher - General Pharmacology: The Vascular System, 1998 - Elsevier
Protein kinase C (PKC) is a family of serine/threonine-directed protein kinases that are
pivotal regulators of cellular growth, transformation and death. PKC has therefore been
considered to be a suitable target for novel antineoplastic drugs. 2. Twenty years ago,
staurosporine was isolated from bacteria and identified as a potent inhibitor of PKC activity.
Its analogs UCN-01 and CGP 41251 effectively arrest the growth of several human-derived
tumor cell lines in vitro. They also possess antineoplastic activity in vivo in human tumors …
pivotal regulators of cellular growth, transformation and death. PKC has therefore been
considered to be a suitable target for novel antineoplastic drugs. 2. Twenty years ago,
staurosporine was isolated from bacteria and identified as a potent inhibitor of PKC activity.
Its analogs UCN-01 and CGP 41251 effectively arrest the growth of several human-derived
tumor cell lines in vitro. They also possess antineoplastic activity in vivo in human tumors …