Activation of calcium entry by the tumor promoter thapsigargin in parotid acinar cells: evidence that an intracellular calcium pool, and not an inositol phosphate …
H Takemura, AR Hughes, O Thastrup… - Journal of Biological …, 1989 - ASBMB
The depletion of an inositol 1, 4, 5-trisphosphate-sensitive intracellular Ca 2+ pool has been
proposed to be the signal for Ca 2+ entry in agonist-activated cells. Consistent with this idea,
thapsigargin, which releases intracellular Ca 2+ without inositol phosphate formation, has
been reported to activate Ca 2+ entry in certain cells. We now report the effects of
thapsigargin on Ca 2+ entry in parotid acinar cells. In fura-2-loaded parotid acinar cells,
thapsigargin caused a sustained elevation of [Ca 2+] i but did not increase inositol …
proposed to be the signal for Ca 2+ entry in agonist-activated cells. Consistent with this idea,
thapsigargin, which releases intracellular Ca 2+ without inositol phosphate formation, has
been reported to activate Ca 2+ entry in certain cells. We now report the effects of
thapsigargin on Ca 2+ entry in parotid acinar cells. In fura-2-loaded parotid acinar cells,
thapsigargin caused a sustained elevation of [Ca 2+] i but did not increase inositol …
