[HTML][HTML] Regulation of disease susceptibility: decreased prevalence of IgE-mediated allergic disease in patients with multiple sclerosis
AS Oro, TJ Guarino, R Driver, L Steinman… - Journal of allergy and …, 1996 - Elsevier
The development of restricted cytokine profiles by subsets of CD4+ T cells is a pivotal point
in the regulation of immune responses. T cells producing Th1 cytokines (IL-2 and interferon-
γ) induce cell-mediated immunity, whereas T cells producing Th2 cytokines (IL-4, IL-5, and
IL-10) play a prominent role in the induction of humoral immunity. We examined a group of
patients with multiple sclerosis, a disease caused by excess production of Th1 cytokines in
myelin-reactive T cells, and control patients with noninflammatory neuroconvulsive …
in the regulation of immune responses. T cells producing Th1 cytokines (IL-2 and interferon-
γ) induce cell-mediated immunity, whereas T cells producing Th2 cytokines (IL-4, IL-5, and
IL-10) play a prominent role in the induction of humoral immunity. We examined a group of
patients with multiple sclerosis, a disease caused by excess production of Th1 cytokines in
myelin-reactive T cells, and control patients with noninflammatory neuroconvulsive …