[HTML][HTML] The CC chemokine monocyte chemotactic peptide-1 activates both the class I p85/p110 phosphatidylinositol 3-kinase and the class II PI3K-C2α
SJ Turner, J Domin, MD Waterfield, SG Ward… - Journal of Biological …, 1998 - ASBMB
The cellular effects of MCP-1 are mediated primarily by binding to CC chemokine receptor-2.
We report here that MCP-1 stimulates the formation of the lipid products of
phosphatidylinositol (PI) 3-kinase, namely phosphatidylinositol 3, 4-bisphosphate and
phosphatidylinositol 3, 4, 5-trisphosphate (PI 3, 4, 5-P 3) in THP-1 cells that can be inhibited
by pertussis toxin but not wortmannin. MCP-1 also stimulates an increase in the in vitro lipid
kinase activity present in immunoprecipitates of the class 1 A p85/p110 heterodimeric PI 3 …
We report here that MCP-1 stimulates the formation of the lipid products of
phosphatidylinositol (PI) 3-kinase, namely phosphatidylinositol 3, 4-bisphosphate and
phosphatidylinositol 3, 4, 5-trisphosphate (PI 3, 4, 5-P 3) in THP-1 cells that can be inhibited
by pertussis toxin but not wortmannin. MCP-1 also stimulates an increase in the in vitro lipid
kinase activity present in immunoprecipitates of the class 1 A p85/p110 heterodimeric PI 3 …