[HTML][HTML] The inositol phosphatase SHIP inhibits Akt/PKB activation in B cells
MJ Aman, TD Lamkin, H Okada, T Kurosaki… - Journal of Biological …, 1998 - ASBMB
The serine-threonine kinase Akt/PKB is activated downstream of phosphatidylinositol 3-
kinase in response to several growth factor stimuli and has been implicated in the promotion
of cell survival. Although both phosphatidylinositol 3, 4, 5-trisphosphate (PIP 3) and
phosphatidylinositol 3, 4-bisphosphate (PI 3, 4-P 2) have been implicated in the regulation
of Akt activity in vitro, the relative roles of these two phospholipids in vivo are not well
understood. Co-ligation of the B cell receptor (BCR) and the inhibitory F c γRIIB1 on B cells …
kinase in response to several growth factor stimuli and has been implicated in the promotion
of cell survival. Although both phosphatidylinositol 3, 4, 5-trisphosphate (PIP 3) and
phosphatidylinositol 3, 4-bisphosphate (PI 3, 4-P 2) have been implicated in the regulation
of Akt activity in vitro, the relative roles of these two phospholipids in vivo are not well
understood. Co-ligation of the B cell receptor (BCR) and the inhibitory F c γRIIB1 on B cells …