[HTML][HTML] The inositol 5′-phosphatase SHIP binds to immunoreceptor signaling motifs and responds to high affinity IgE receptor aggregation
MA Osborne, G Zenner, M Lubinus, X Zhang… - Journal of Biological …, 1996 - ASBMB
Immunoreceptors such as the high affinity IgE receptor, FcϵRI, and T-cell receptor-
associated proteins share a common motif, the immunoreceptor tyrosine-based activation
motif (ITAM). We used the yeast tribrid system to identify downstream effectors of the
phosphorylated FcϵRI ITAM-containing subunits β and γ. One novel cDNA was isolated that
encodes a protein that is phosphorylated on tyrosine, contains a Src-homology 2 (SH2)
domain, inositolpolyphosphate 5-phosphatase activity, three NXXY motifs, several proline …
associated proteins share a common motif, the immunoreceptor tyrosine-based activation
motif (ITAM). We used the yeast tribrid system to identify downstream effectors of the
phosphorylated FcϵRI ITAM-containing subunits β and γ. One novel cDNA was isolated that
encodes a protein that is phosphorylated on tyrosine, contains a Src-homology 2 (SH2)
domain, inositolpolyphosphate 5-phosphatase activity, three NXXY motifs, several proline …