[HTML][HTML] Molecular basis for ADP-induced platelet activation: II. The P2Y1 receptor mediates ADP-induced intracellular calcium mobilization and shape change in …

J Jin, JL Daniel, SP Kunapuli - Journal of Biological Chemistry, 1998 - ASBMB
ADP is an important platelet agonist causing shape change from smooth discoid shape to
spiculated spheres and platelet aggregation. However, the molecular mechanisms involved
in ADP-induced platelet activation have not been elucidated. We demonstrated earlier the
existence of two distinct ADP receptors on platelets, one coupled to phospholipase C, P2T
PLC, and the other to inhibition of adenylyl cyclase, P2T AC (Daniel, JL, Dangelmaier, C.,
Jin, J., Ashby, B., Smith, JB, and Kunapuli, SP (1998) J. Biol. Chem. 273, 2024–2029), in …