How subtle differences in MHC class II affect the severity of experimental myasthenia gravis
B Yang, KR McIntosh, DB Drachman - Clinical immunology and …, 1998 - Elsevier
Myasthenia gravis is an autoimmune disorder characterized by muscle weakness, due to an
antibody-mediated deficit of acetylcholine receptors (AChRs) at neuromuscular junctions.
We analyzed the factors that determine the severity of experimental myasthenia gravis
(EAMG) induced by immunization withTorpedoAChR, in two congenic strains of mice—B6
mice, which are highly susceptible to EAMG; and bm12 mice, which are relatively resistant,
and differ only in a change of three amino acids in MHC Class II. We prepared large …
antibody-mediated deficit of acetylcholine receptors (AChRs) at neuromuscular junctions.
We analyzed the factors that determine the severity of experimental myasthenia gravis
(EAMG) induced by immunization withTorpedoAChR, in two congenic strains of mice—B6
mice, which are highly susceptible to EAMG; and bm12 mice, which are relatively resistant,
and differ only in a change of three amino acids in MHC Class II. We prepared large …