Chronic allograft nephropathy in the rat is improved by angiotensin II receptor blockade but not by calcium channel antagonism.
SC Amuchastegui, N Azzollini, M Mister… - Journal of the …, 1998 - journals.lww.com
Functional and structural changes of chronic renal allograft failure share similarities with
other chronic nephropathies with low nephron number. In models of reduced nephron
number, angiotensin-converting enzyme inhibitors or angiotensin II receptor blockers
prevented proteinuria and retarded renal lesions. This study investigates whether blockade
of angiotensin II activity prevented chronic allograft injury in the Fisher 344--> Lewis rat
kidney transplant model, and compares its effect with that of calcium channel blockers, the …
other chronic nephropathies with low nephron number. In models of reduced nephron
number, angiotensin-converting enzyme inhibitors or angiotensin II receptor blockers
prevented proteinuria and retarded renal lesions. This study investigates whether blockade
of angiotensin II activity prevented chronic allograft injury in the Fisher 344--> Lewis rat
kidney transplant model, and compares its effect with that of calcium channel blockers, the …