Tubular atrophy in the end-stage kidney: a lectin and immunohistochemical study
T Nadasdy, Z Laszik, KE Blick, DL Johnson, FG Silva - Human pathology, 1994 - Elsevier
Atrophic tubules in end-stage renal disease (ESRD) may have various morphologic
appearances: some show microscopic features of “classic” atrophic tubules (thick, wrinkled
tubular basement membrane and simplified epithelium), others show “thyroidization”(round
tubules with simplified epithelium and casts), and many have the appearance of “endocrine”
tubules (small tubules with narrow lumina, clear cells, and relatively thin basement
membranes). Other tubules in ESRD may be enlarged and dilated with hypertrophic cells …
appearances: some show microscopic features of “classic” atrophic tubules (thick, wrinkled
tubular basement membrane and simplified epithelium), others show “thyroidization”(round
tubules with simplified epithelium and casts), and many have the appearance of “endocrine”
tubules (small tubules with narrow lumina, clear cells, and relatively thin basement
membranes). Other tubules in ESRD may be enlarged and dilated with hypertrophic cells …