Human papillomavirus DNA in genital tract lesions histologically negative for condylomata: analysis by in situ, Southern blot hybridization and the polymerase chain …
GJ Nuovo - The American journal of surgical pathology, 1990 - journals.lww.com
Koilocytotic atypia (nuclear atypia in conjunction with perinuclear halos) is diagnostic of
condylomata of the lower female genital tract, over 90% of which contain human
papillomavirus (HPV) DNA. Genital tract lesions may be clinically suggestive of condylomata
but lack clear-cut koilocytotic atypia. Of 57 vulvar and 60 cervical lesions that lacked clear-
cut koilocytotic atypia, four (7%) and two (3%), respectively, had HPV DNA detected by in
situ analysis. Using Southern blot analysis, HPV DNA was detected in five of 27 (19%) and …
condylomata of the lower female genital tract, over 90% of which contain human
papillomavirus (HPV) DNA. Genital tract lesions may be clinically suggestive of condylomata
but lack clear-cut koilocytotic atypia. Of 57 vulvar and 60 cervical lesions that lacked clear-
cut koilocytotic atypia, four (7%) and two (3%), respectively, had HPV DNA detected by in
situ analysis. Using Southern blot analysis, HPV DNA was detected in five of 27 (19%) and …