Effects of pyruvate, l-lactate, and 3-phenylpyruvate on function of obob mouse pancreatic islets: Insulin secretion in relation to 45Ca2+ uptake and metabolism
S Lenzen, U Panten - Biochemical medicine, 1981 - Elsevier
Pyruvate and l-lactate, at concentrations up to 40 mm, did not cause insulin release and 45
Ca 2+ uptake by isolated incubated ob ob mouse pancreatic islets. Insulin secretion by
perfused ob ob mouse pancreas was neither initiated nor potentiated by pyruvate or l-
lactate. However,[U-14 C] pyruvate oxidation rates by pancreatic islets were five to nine
times higher than l-[U-14] lactate oxidation rates. 3-Phenylpyruvate induced concentration-
dependent insulin release and 45 Ca 2+ uptake by incubated pancreatic islets and a …
Ca 2+ uptake by isolated incubated ob ob mouse pancreatic islets. Insulin secretion by
perfused ob ob mouse pancreas was neither initiated nor potentiated by pyruvate or l-
lactate. However,[U-14 C] pyruvate oxidation rates by pancreatic islets were five to nine
times higher than l-[U-14] lactate oxidation rates. 3-Phenylpyruvate induced concentration-
dependent insulin release and 45 Ca 2+ uptake by incubated pancreatic islets and a …