A unique sodium-hydrogen exchange isoform (NHE-4) of the inner medulla of the rat kidney is induced by hyperosmolarity.
C Bookstein, MW Musch, A DePaoli, Y Xie… - Journal of Biological …, 1994 - ASBMB
Membrane sodium-hydrogen exchangers (NHEs), found in virtually all cell types, appear to
have diverse and essential roles in regulating cellular pH and mediating vectorial transport
by epithelial cells. However, the functional and physiological role of the recently cloned
isoform NHE-4 remains unknown. Unlike other Na-H exchanger isoforms, NHE-4 transfected
into NHE-deficient mutant fibroblasts demonstrated no amiloride-inhibitable sodium uptake,
under basal or acid-loaded isoosmotic conditions. By immunoblot analysis, only the NHE-4 …
have diverse and essential roles in regulating cellular pH and mediating vectorial transport
by epithelial cells. However, the functional and physiological role of the recently cloned
isoform NHE-4 remains unknown. Unlike other Na-H exchanger isoforms, NHE-4 transfected
into NHE-deficient mutant fibroblasts demonstrated no amiloride-inhibitable sodium uptake,
under basal or acid-loaded isoosmotic conditions. By immunoblot analysis, only the NHE-4 …