[HTML][HTML] Role of NHE3 in mediating renal brush border Na+-H+ exchange: adaptation to metabolic acidosis
MS Wu, D Biemesderfer, G Giebisch… - Journal of Biological …, 1996 - ASBMB
The aims of the present study were to estimate the fraction of renal brush border membrane
Na+-H+ exchange activity mediated by the isoform NHE3 and to evaluate whether the
increased brush border Na+-H+ exchange observed in metabolic acidosis is due to
increased expression of NHE3 protein. Compared with other isoforms, NHE3 is known to
have a unique profile of sensitivity to pharmacologic inhibitors, including relative resistance
to amiloride analogs and HOE694. We therefore assessed the inhibitor sensitivity of pH …
Na+-H+ exchange activity mediated by the isoform NHE3 and to evaluate whether the
increased brush border Na+-H+ exchange observed in metabolic acidosis is due to
increased expression of NHE3 protein. Compared with other isoforms, NHE3 is known to
have a unique profile of sensitivity to pharmacologic inhibitors, including relative resistance
to amiloride analogs and HOE694. We therefore assessed the inhibitor sensitivity of pH …