Data obtained while investigating growth plate chondrocyte differentiation during
endochondral bone formation both in vivo and in vitro indicate that initial chondrogenesis
depends on positional signaling mediated by selected homeobox-containing genes and
soluble mediators. Continuation of the process strongly relies on interactions of the
differentiating cells with the microenvironment, that is, other cells and extracellular matrix.
Production of and response to different hormones and growth factors are observed at all …