Toward a molecular understanding of skeletal development
A Erlebacher, EH Filvaroff, SE Gitelman, R Derynck - Cell, 1995 - cell.com
A Erlebacher, EH Filvaroff, SE Gitelman, R Derynck
Cell, 1995•cell.comThe HIV-1 matrix (MA) protei n contains two subcellular localization signals with opposing
effects. A myristoylated N-terminus governs particle assembly at the plasma membrane, and
a nucleophilic motif facilitates import of the viral preintegration complex into the nucleus of
nondividing cells. Here, we show that myristoylation acts as the MA dominant targeting
signal in HIV-1 producer cells. During virus assembly, a subset of MA is phosphorylated on
the C-terminal tyrosine by a virion-associated cellular protein kinase.
effects. A myristoylated N-terminus governs particle assembly at the plasma membrane, and
a nucleophilic motif facilitates import of the viral preintegration complex into the nucleus of
nondividing cells. Here, we show that myristoylation acts as the MA dominant targeting
signal in HIV-1 producer cells. During virus assembly, a subset of MA is phosphorylated on
the C-terminal tyrosine by a virion-associated cellular protein kinase.
The HIV-1 matrix (MA) protei n contains two subcellular localization signals with opposing effects. A myristoylated N-terminus governs particle assembly at the plasma membrane, and a nucleophilic motif facilitates import of the viral preintegration complex into the nucleus of nondividing cells. Here, we show that myristoylation acts as the MA dominant targeting signal in HIV-1 producer cells. During virus assembly, a subset of MA is phosphorylated on the C-terminal tyrosine by a virion-associated cellular protein kinase.
cell.com