Induction of gelatinase B and MCP-2 in baboons during sublethal and lethal bacteraemia
L Paemen, PM Jansen, P Proost, J Van Damme… - Cytokine, 1997 - Elsevier
L Paemen, PM Jansen, P Proost, J Van Damme, G Opdenakker, E Hack, FB Taylor
Cytokine, 1997•ElsevierIntravenous injection or sublethal of lethal doses ofEscherichia coliin baboons resulted in
increased serum levels of the matrix metalloprotease gelatinase B and the chemokine
monocyte chemotactic protein 2 (MCP-2). In both animal models, gelatinase B appeared
faster than MCP-2. After sublethal challenge, serum levels of gelatinase B and MCP-2 were
found to be correlated, reaching peak levels between 2 and 4 h after bacterial challenge.
After lethal challenge, however, MCP-2 tended to increase until 10 h. The kinetics of …
increased serum levels of the matrix metalloprotease gelatinase B and the chemokine
monocyte chemotactic protein 2 (MCP-2). In both animal models, gelatinase B appeared
faster than MCP-2. After sublethal challenge, serum levels of gelatinase B and MCP-2 were
found to be correlated, reaching peak levels between 2 and 4 h after bacterial challenge.
After lethal challenge, however, MCP-2 tended to increase until 10 h. The kinetics of …
Intravenous injection or sublethal of lethal doses ofEscherichia coliin baboons resulted in increased serum levels of the matrix metalloprotease gelatinase B and the chemokine monocyte chemotactic protein 2 (MCP-2). In both animal models, gelatinase B appeared faster than MCP-2. After sublethal challenge, serum levels of gelatinase B and MCP-2 were found to be correlated, reaching peak levels between 2 and 4 h after bacterial challenge. After lethal challenge, however, MCP-2 tended to increase until 10 h. The kinetics of appearance suggest induction of release of gelatinase B andde novosynthesis and secretion of MCP-2, both by endotoxin.
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