Negative control elements of the cell cycle in human tumors
PD Adams, WG Kaelin Jr - Current opinion in cell biology, 1998 - Elsevier
PD Adams, WG Kaelin Jr
Current opinion in cell biology, 1998•ElsevierThe retinoblastoma protein and p53 are both cell-cycle regulators and are, directly or
indirectly, inactivated in the majority of human tumors. Recent studies have provided new
mechanistic insights into how these proteins regulate cell growth in response to various
intracellular and extracellular signals.
indirectly, inactivated in the majority of human tumors. Recent studies have provided new
mechanistic insights into how these proteins regulate cell growth in response to various
intracellular and extracellular signals.
The retinoblastoma protein and p53 are both cell-cycle regulators and are, directly or indirectly, inactivated in the majority of human tumors. Recent studies have provided new mechanistic insights into how these proteins regulate cell growth in response to various intracellular and extracellular signals.
Elsevier