Simultaneous quantitative determination of the HIV protease inhibitors amprenavir, indinavir, nelfinavir, ritonavir and saquinavir in human plasma by ion-pair high …
RPG Van Heeswijk, RMW Hoetelmans, R Harms… - … of Chromatography B …, 1998 - Elsevier
A reversed-phase high-performance liquid chromatographic assay for the simultaneous
quantitative determination of five HIV protease inhibitors (ie amprenavir, indinavir, nelfinavir,
ritonavir, and saquinavir) in human plasma is described. Sample pretreatment consisted of
solid-phase extraction prior to ion-pair, reversed-phase high-performance liquid
chromatography with ultraviolet detection at 210 nm (amprenavir, indinavir and nelfinavir)
and 239 nm (saquinavir and ritonavir). For amprenavir, indinavir and saquinavir the method …
quantitative determination of five HIV protease inhibitors (ie amprenavir, indinavir, nelfinavir,
ritonavir, and saquinavir) in human plasma is described. Sample pretreatment consisted of
solid-phase extraction prior to ion-pair, reversed-phase high-performance liquid
chromatography with ultraviolet detection at 210 nm (amprenavir, indinavir and nelfinavir)
and 239 nm (saquinavir and ritonavir). For amprenavir, indinavir and saquinavir the method …