Isolation and characterization of a macrophage-derived high molecular weight protein involved in the regulation of mucus-like glycoconjugate secretion

EG Gollub, SK Goswami, K Sperber, Z Marom - Journal of allergy and …, 1992 - Elsevier
Pulmonary macrophages release a variety of mediators that are involved in inflammatory
processes and probably are involved in respiratory mucus secretion. Conditioned media
obtained from activated pulmonary macrophages were found to contain a protein that
functioned as a secretagogue for mucus-like glycoconjugate (MLGC) in an in vitro bioassay.
A human macrophage-derived hybridoma cell line, HB-63, exhibited the same properties
and was very useful in obtaining large amounts of the protein for purification and …