Mucus secretagogue production by a human macrophage hybridoma
K Sperber, SK Goswami, E Gollub, L Mayer… - Journal of allergy and …, 1991 - Elsevier
A pulmonary macrophage-monocyte-derived mucus secretagogue (MMS) oligopeptide has
been previously reported to induce mucus secretion in an in vitro model system with human
airway explants and secretory epithelial cells. To understand the possible role of
macrophages in the regulation of secretion of mucus, our laboratory has used a series of
human macrophage hybridomas that were generated by fusing an hypoxanthine guanine
phosphoribosyl transferase-deficient promonocytic line, U937, with macrophages obtaining …
been previously reported to induce mucus secretion in an in vitro model system with human
airway explants and secretory epithelial cells. To understand the possible role of
macrophages in the regulation of secretion of mucus, our laboratory has used a series of
human macrophage hybridomas that were generated by fusing an hypoxanthine guanine
phosphoribosyl transferase-deficient promonocytic line, U937, with macrophages obtaining …