Interaction of ion channels and receptors with PDZ domain proteins

HC Kornau, PH Seeburg, MB Kennedy - Current opinion in neurobiology, 1997 - Elsevier
HC Kornau, PH Seeburg, MB Kennedy
Current opinion in neurobiology, 1997Elsevier
The complex anatomy of neurons demands a high degree of functional organization.
Therefore, membrane receptors and ion channels are often localized to selected subcellular
sites and coupled to specific signal transduction machineries. PDZ domains have come into
focus as protein interaction modules that mediate the binding of a class of submembraneous
proteins to membrane receptors and ion channels and thus subserve these organizational
aspects. The structures of two PDZ domains have been resolved, which has led to a …
The complex anatomy of neurons demands a high degree of functional organization. Therefore, membrane receptors and ion channels are often localized to selected subcellular sites and coupled to specific signal transduction machineries. PDZ domains have come into focus as protein interaction modules that mediate the binding of a class of submembraneous proteins to membrane receptors and ion channels and thus subserve these organizational aspects. The structures of two PDZ domains have been resolved, which has led to a structural understanding of the specificity of interactions of various PDZ domains with their respective partners. The functional implications of PDZ domain interactions are now being addressed in vitro and in vivo.
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