[HTML][HTML] Cystic fibrosis transmembrane conductance regulator-associated ATP and adenosine 3′-phosphate 5′-phosphosulfate channels in endoplasmic reticulum …

EA Pasyk, JK Foskett - Journal of Biological Chemistry, 1997 - ASBMB
Cystic fibrosis (CF) is characterized by abnormal regulation of epithelial ion and fluid
transport due to mutations in the CF transmembrane conductance regulator (CFTR), an
apical membrane-localized Cl− channel, that usually prevent it from exiting the endoplasmic
reticulum. Defective or absent CFTR in the epithelium is believed to disrupt fluid balance in
human airways and thereby contribute to chronic respiratory inflammation. Patch-clamp of
the plasma membrane and outer membrane of the nuclear envelope of nuclei isolated from …