Neurohormonal regulation of histamine and pancreastatin secretion from isolated rat stomach ECL cells
E Lindström, M Björkqvist, Å Boketoft, D Chen… - Regulatory peptides, 1997 - Elsevier
ECL cells are numerous in the acid-producing part of the rat stomach. They are rich in
histamine and pancreastatin, a chromogranin A-derived peptide, and they secrete these
products in response to gastrin. We have examined how isolated ECL cells respond to a
variety of neuromessengers and peptide hormones. Highly purified (85%) ECL cells were
collected from rat stomach using repeated counter-flow elutriation and cultured for 48 h
before experiments were conducted. The ECL cells responded to gastrin, sulphated …
histamine and pancreastatin, a chromogranin A-derived peptide, and they secrete these
products in response to gastrin. We have examined how isolated ECL cells respond to a
variety of neuromessengers and peptide hormones. Highly purified (85%) ECL cells were
collected from rat stomach using repeated counter-flow elutriation and cultured for 48 h
before experiments were conducted. The ECL cells responded to gastrin, sulphated …