Role of acetylcholine, histamine and gastrin in the acid response to intracisternal injection of TRH analog, RX 77368, in the rat
K Yanagisawa, H Yang, JH Walsh, Y Taché - Regulatory peptides, 1990 - Elsevier
The role of gastrin, acetylcholine and histamine in the acid response to central vagal
activation induced by intracisternal injection of the stable analog, RX 77368, was further
investigated in urethane-anesthetized rats with gastric fistula. The gastrin monoclonal
antibody 28-2 injected intravenously, at a dose previously shown to prevent gastrin-induced
stimulation of acid secretion, did not alter the peak acid response to intracisternal injection of
RX 77368 (15 ng). The TRH analog (30 ng) injected into the cisterna magna increased …
activation induced by intracisternal injection of the stable analog, RX 77368, was further
investigated in urethane-anesthetized rats with gastric fistula. The gastrin monoclonal
antibody 28-2 injected intravenously, at a dose previously shown to prevent gastrin-induced
stimulation of acid secretion, did not alter the peak acid response to intracisternal injection of
RX 77368 (15 ng). The TRH analog (30 ng) injected into the cisterna magna increased …