Endoglin is an accessory protein that interacts with the signaling receptor complex of multiple members of the transforming growth factor-β superfamily
NP Barbara, JL Wrana, M Letarte - Journal of Biological Chemistry, 1999 - ASBMB
Endoglin (CD105) is a transmembrane glycoprotein that binds transforming growth factor
(TGF)-β1 and-β3, and coprecipitates with the Ser/Thr kinase signaling receptor complex by
affinity labeling of endothelial and leukemic cells. The present study shows that in addition to
TGF-β1 and-β3, endoglin interacts with activin-A, bone morphogenetic protein (BMP)-7, and
BMP-2 but requires coexpression of the respective ligand binding kinase receptor for this
association. Endoglin cannot bind ligands on its own and does not alter binding to the …
(TGF)-β1 and-β3, and coprecipitates with the Ser/Thr kinase signaling receptor complex by
affinity labeling of endothelial and leukemic cells. The present study shows that in addition to
TGF-β1 and-β3, endoglin interacts with activin-A, bone morphogenetic protein (BMP)-7, and
BMP-2 but requires coexpression of the respective ligand binding kinase receptor for this
association. Endoglin cannot bind ligands on its own and does not alter binding to the …
