Enhanced release of nitric oxide in response to changes in flow and shear stress in the superior mesenteric arteries of portal hypertensive rats
N Hori, R Wiest, RJ Groszmann - Hepatology, 1998 - journals.lww.com
Increased nitric oxide (NO) release has been implicated in the pathogenesis of the
hyperdynamic circulation in portal hypertension. NOS 3 (eNOS) causes NO release from the
endothelium in response to physical stimuli, such as increased blood flow and shear stress.
We evaluated the functional activity of the endothelium in the superior mesenteric arterial
bed of portal hypertensive rats through direct measurement of NO metabolites (NO x) during
changes in flow and shear stress. The in vitro perfusion system (McGregor) was used in …
hyperdynamic circulation in portal hypertension. NOS 3 (eNOS) causes NO release from the
endothelium in response to physical stimuli, such as increased blood flow and shear stress.
We evaluated the functional activity of the endothelium in the superior mesenteric arterial
bed of portal hypertensive rats through direct measurement of NO metabolites (NO x) during
changes in flow and shear stress. The in vitro perfusion system (McGregor) was used in …