Response of psoriasis to a new topical retinoid, AGN 190168
T Esgleyes-Ribot, RA Chandraratna… - Journal of the American …, 1994 - Elsevier
Background: Oral retinoids have been widely used in psoriasis, but topical forms have been
ineffective or irritating. Objective: Our purpose was to determine the clinical and molecular
effects of a new topical retinoid, AGN 190168, on psoriasis. Methods: Seven patients with
psoriasis were treated for 2 weeks with topical retinoid and 2 weeks with vehicle. Two
control subjects with psoriasis were treated for 2 weeks with vehicle alone. Biopsy
specimens from normal skin as well as from untreated and treated psoriatic lesions were …
ineffective or irritating. Objective: Our purpose was to determine the clinical and molecular
effects of a new topical retinoid, AGN 190168, on psoriasis. Methods: Seven patients with
psoriasis were treated for 2 weeks with topical retinoid and 2 weeks with vehicle. Two
control subjects with psoriasis were treated for 2 weeks with vehicle alone. Biopsy
specimens from normal skin as well as from untreated and treated psoriatic lesions were …