The instructive role of innate immunity in the acquired immune response

DT Fearon, RM Locksley - Science, 1996 - science.org
Science, 1996science.org
Innate immunity has been considered only to provide rapid, incomplete antimicrobial host
defense until the slower, more definitive acquired immune response develops. However,
innate immunity may have an additional role in determining which antigens the acquired
immune system responds to and the nature of that response. Knowledge of the molecules
and pathways involved may create new therapeutic options for infectious and autoimmune
diseases.
Innate immunity has been considered only to provide rapid, incomplete antimicrobial host defense until the slower, more definitive acquired immune response develops. However, innate immunity may have an additional role in determining which antigens the acquired immune system responds to and the nature of that response. Knowledge of the molecules and pathways involved may create new therapeutic options for infectious and autoimmune diseases.
AAAS