Response of murine and normal human skin to injection of allogeneic blood-derived psoriatic immunocytes: detection of T cells expressing receptors typically present …
BJ Nickoloff, T Wrone-Smith, B Bonish… - Archives of …, 1999 - jamanetwork.com
Background The genetic and immunological basis for psoriasis is unknown. Through the
use of a severe combined immunodeficient mouse–human skin model, T cells have been
shown to induce psoriasis, which points to a pathological role for such immunocompetent
cells. During ongoing studies using this model, a previously overlooked subset of
immunocytes expressing receptors typically present on natural killer (NK) cells was
discovered, which may shed new light on the genetic susceptibility for psoriasis …
use of a severe combined immunodeficient mouse–human skin model, T cells have been
shown to induce psoriasis, which points to a pathological role for such immunocompetent
cells. During ongoing studies using this model, a previously overlooked subset of
immunocytes expressing receptors typically present on natural killer (NK) cells was
discovered, which may shed new light on the genetic susceptibility for psoriasis …