Cyclic AMP stimulates efflux of intracellular sterol from cholesterol-loaded cells.
BM Hokland, JP Slotte, EL Bierman, JF Oram - Journal of Biological …, 1993 - ASBMB
The interaction of high density lipoprotein with its putative receptor stimulates translocation
and efflux of intracellular sterols by a process involving activation of protein kinase C. This
study shows that activation of cAMP-dependent protein kinase also stimulates efflux of
intracellular sterols. When intracellular sterol pools of cholesterol-loaded cultured human
skin fibroblasts and bovine aortic endothelial cells were radiolabeled with the biosynthetic
precursor [3H] mevalonolactone, high density lipoprotein3 (HDL3)-mediated 3H-sterol efflux …
and efflux of intracellular sterols by a process involving activation of protein kinase C. This
study shows that activation of cAMP-dependent protein kinase also stimulates efflux of
intracellular sterols. When intracellular sterol pools of cholesterol-loaded cultured human
skin fibroblasts and bovine aortic endothelial cells were radiolabeled with the biosynthetic
precursor [3H] mevalonolactone, high density lipoprotein3 (HDL3)-mediated 3H-sterol efflux …