Negative modulation of nitric oxide synthase by nitric oxide and nitroso compounds

JM Griscavage, AJ Hobbs, LJ Ignarro - Advances in pharmacology, 1995 - Elsevier
Publisher Summary Nitric oxide (NO) inhibits nitric oxide synthase (NOS) activity and nNOS
and eNOS are more sensitive than iNOS to the inhibitory action of NO. Not only exogenously
added NO but also enzymatically generated NO inhibits the activity of nNOS and eNOS. The
original observation that proved NO inhibits NOS activity has been made using unpurified
preparations of nNOS obtained from rat cerebellum. Enzymatically generated NO also
inhibits nNOS activity. For this purpose, NO was tested for its inhibitory effect on unpurified …